
The giant chimp Titano first appeared in Superman #127 (Feb 1959) -- originally named Toto, he was rocketed into space where his ship was bombarded with radiation. The results changed him into a giant ape with incredible strength that could shoot beams of Kryptonite radiation from his eyes. (As you can see from the cover of DC Special #16 below, DC Comics was big on "apes" during the 1950s and '60s.)
Excerpts from the Superman: The Animated Series 1997 episode "Monkey Fun"
Related links:
King Kong Escapes (1967) Trailer
King Kong vs. Godzilla (1962) Trailer
KONG SURVIVES!
Giant Monster Movies: King Kong (and other Giant Apes)
Giant Monster Movies